So far, CNV histograms and .pgxseg segment and matrix files used a 1Mb genome binning,
based on the consecutive assignment of 1Mb intervals from 1pter -> Yqter. This resulted
in **3102** intervals, with the last interval of each chromosome being smaller.

On 2022-02-11 we have changed the procedure. Now, the last interval of the short arm of any chromosome is terminated at the centromere, leading to

- a (potentially) shortened “last p” interval
- a shift of most interval positions
- a changed interval number from 3102 to
**3106**

Also, since a few qter intervals were very small we now use a padding factor (currently 100000 bases) to determine if the last band would be smaller - in which case it is discarded and the previous interval extended to cover up to the telomere. This applies to chromosomes 6 and X, where the last intervals become now slightly larger than 1Mb:

- X:155000000-156040895, size 1040895
- 6:169800000-170805979, size 1005979

Since many CNVs have natural breakpoints at chromosomal centromeres the new interval mapping should provide a better representation of genomic events. Also, such a mapping facilitates the calculation of e.g. arm specific CNV fractions which are sometimes used as statistical indicators. Enjoy!

@mbaudis 2022-02-11: more ...